toxic effect of intravitreal carboplatin detected by flattened electeroretinogram in a patient with retinoblastoma treated by chemoreduction and local treatments

purpose : the first report of electroretinographic changes following the intravitreal injection of carboplatin in a patient with retinoblastoma case report : recurrent tumors after chemoreduction and adjunctive local treatment in a case of familial unilateral retinoblastoma, group c, was treated with intravitreal carboplatin (10 µg) injections. results : the tumor was regressed after 3 injections. flat electeroretinogram (erg) amplitude was noted following the intravitreal injection of carboplatin. after nearly one year tumor-free period in this case, visual acuity (va) in the affected eye was 20/800 despite a flat erg. conclusion : intravitreal carboplatin can effectively treat intraretinal tumor recurrences but de-novo tumors can be produced causing therapeutic problems. intravitreal injections of carboplatin can cause retinal toxicity and flat erg.    iranian journal of ophthalmology 201022(3):57-60 © 2010 by the iranian society of ophthalmology